Cardiometrix

Lowering high blood pressure is associated with significant reduction in all major cardiovascular events, all-cause mortality, stroke, coronary events, and heart failure. Since medicine is still not personalized neither particularly precise, guidelines  for choosing the right drug keep evolving.  For adults with hypertension requiring pharmacological treatment, the following three classes of pharmacological antihypertensive medications are used as an initial treatment: diuretics , ACE inhibitors or ARBs , and calcium channel blockers.  ACE inhibitors (ACEIs) reduce the activity of the angiotensin-converting enzyme (ACE) which is responsible for hormones that help control blood pressure.  Synthetic ACE inhibitors, such as captopril, enalapril, lisinopril, and temocapril, are in clinical use for the treatment of hypertension. Lisinopril is found to have significant negative effect on perceptual motor skills, thus other ACE inhibitors such as Benazepril, Fosinopril,...

P otentially lethal inherited arrhythmia syndromes could be inherited. The list of potentially associated genes is growing.  Long QT syndrome has been linked with LQTS;  KCNH2 ,  KCNQ1 ,  SCN5A;  Brugada syndrome to  SCN5A , arrhythmogenic cardiomyopathy to  LMNA , and catecholamine-induced polymorphic ventricular tachycardia to RYR2 .  Characteristic TU–Wave Patterns Predict the KCNJ2 Genotype eMERGE-III  study analyzes phenotype and genotype data for individuals with health problems as well as healthy volunteers.  Through  this study,  109 Mendelian disease genes, including 10 associated with arrhythmias, were sequenced in 21,846 individuals who had no indication for arrythmia-related genetic testing. In 1,838 patients, researchers found never-before-seen variations in the 10 genes associated with genetic arrhythmia, highlighting the problem of variants of unknown significance in the  new era of genomic medicine for card...